記事インデックス

1999年以前

  1. Fukasawa M, Nishijima M, *Hanada K (1999) Genetic evidence for ATP-dependent endoplasmic reticulum-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in Chinese hamster ovary cells, J Cell Biol, 144, 673-685. (Open access: http://jcb.rupress.org/content/144/4/673.long)
  2. Suzuki T, Suzuki Y, Hanada K, Hashimoto A, Redpath JL, Stanbridge EJ, Nishijima M, *Kitagawa T (1998) Reduction of caveolin-1 expression in tumorigenic human cell hybrids, J Biochem, 124, 383-388.
  3. *Kobayashi S, Furuta T, Hayashi T, Nishijima M, Hanada K (1998) Catalytic asymmetric syntheses of antifungal sphingofungins and their biological activity as potent inhibitors of serine palmitoyltransferase (SPT), J Am Chem Soc, 200, 908-919.
  4. *Hanada K, Hara T, Fukasawa M, Yamaji A, Umeda M, Nishijima M (1998) Mammalian cell mutants resistant to a sphingomyelin-directed cytolysin. Genetic and biochemical evidence for complex formation of the LCB1 protein with the LCB2 protein for serine palmitoyltransferase, J Biol Chem, 273, 33787-33794. (Open access: http://www.jbc.org/content/273/50/33787.long)
  5. Yamamoto H, Hanada K, *Nishijima M (1997) Involvement of diacylglycerol production in activation of nuclear factor kappaB by a CD14-mediated lipopolysaccharide stimulus, Biochem J, 325 ( Pt 1), 223-228.
  6. Yamamoto H, Hanada K, Kawasaki K, *Nishijima M (1997) Inhibitory effect on curcumin on mammalian phospholipase D activity, FEBS Lett, 417, 196-198.
  7. *Hanada K, Hara T, Nishijima M, Kuge O, Dickson RC, Nagiec MM (1997) A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis, J Biol Chem, 272, 32108-32114. (Open access: http://www.jbc.org/content/272/51/32108.long)
  8. Fukasawa M, Sekine F, Miura M, Nishijima M, *Hanada K (1997) Involvement of heparan sulfate proteoglycans in the binding step for phagocytosis of latex beads by Chinese hamster ovary cells, Exp Cell Res, 230, 154-162. doi: 10.1006/excr.1996.3403.
  9. Hanada K, *Pagano RE (1995) A Chinese hamster ovary cell mutant defective in the non-endocytic uptake of fluorescent analogs of phosphatidylserine: isolation using a cytosol acidification protocol, J. Cell Biol., 128, 793-804.
  10. *Hanada K, Nishijima M, Akamatsu Y, Pagano RE (1995) Both sphingolipids and cholesterol participate in the detergent insolubility of alkaline phosphatase, a glycosylphosphatidylinositol-anchored protein, in mammalian membranes, J Biol Chem, 270, 6254-6260. (Open access: http://www.jbc.org/content/270/11/6254.long)
  11. *Hanada K, Izawa K, Nishijima M, Akamatsu Y (1993) Sphingolipid deficiency induces hypersensitivity of CD14, a glycosyl phosphatidylinositol-anchored protein, to phosphatidylinositol-specific phospholipase C, J Biol Chem, 268, 13820-13823. (Open access: http://www.jbc.org/content/268/19/13820.long)
  12. Hanada K, Yoshida T, Yamato I, *Anraku Y (1992) Sodium ion and proline binding sites in the Na+/proline symport carrier of Escherichia coli, Biochim Biophys Acta, 1105, 61-66.
  13. *Hanada K, Nishijima M, Kiso M, Hasegawa A, Fujita S, Ogawa T, Akamatsu Y (1992) Sphingolipids are essential for the growth of Chinese hamster ovary cells. Restoration of the growth of a mutant defective in sphingoid base biosynthesis by exogenous sphingolipids, J Biol Chem, 267, 23527-23533. (Open access: http://www.jbc.org/content/267/33/23527.long)
  14. *Hanada K, Horii M, Akamatsu Y (1991) Functional reconstitution of sphingomyelin synthase in Chinese hamster ovary cell membranes, Biochim Biophys Acta, 1086, 151-156.
  15. *Hanada K, Nishijima M, Akamatsu Y (1990) A temperature-sensitive mammalian cell mutant with thermolabile serine palmitoyltransferase for the sphingolipid biosynthesis, J Biol Chem, 265, 22137-22142. (Open access: http://www.jbc.org/content/265/36/22137.long)
  16. Komeiji Y, Hanada K, Yamato I, *Anraku Y (1989) Orientation of the carboxyl terminus of the Na+/proline symport carrier in Escherichia coli, FEBS Lett, 256, 135-138.
  17. Hanada K, Yamato I, *Anraku Y (1988) Solubilization and reconstitution of proline carrier in Escherichia coli; quantitative analysis and optimal conditions, Biochim Biophys Acta, 939, 282-288.
  18. Hanada K, Yamato I, *Anraku Y (1988) Purification and reconstitution of Escherichia coli proline carrier using a site specifically cleavable fusion protein, J Biol Chem, 263, 7181-7185. (Open access: http://www.jbc.org/content/263/15/7181.long)
  19. Hanada K, Yamato I, *Anraku Y (1987) Construction and properties of bifunctionally active membrane-bound fusion proteins. Escherichia coli proline carrier linked with beta-galactosidase, J Biol Chem, 262, 14100-14104. (Open access: http://www.jbc.org/content/262/29/14100.long)
  20. Hanada K, Yamato I, *Anraku Y (1985) Identification of proline carrier in Escherichia coli K-12, FEBS Lett, 191, 278-282.

 

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花田業績リスト                                                                          2016.8.15.更新

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2016

*Hanada K, and Sugiki T (2016): In vitro assay to extract specific lipid types from phospholipid membranes using lipid-transfer proteins: a lesson from the ceramide transport protein CERT, Neuromethods, in press.

Hernández-Tiedra S, Fabrias G, Salanueva IJ, Casas J, Dávila D, Montes RL, Antón Z, García-Taboada E, Salazar M, Lorente M, Nylandsted J, Armstrong J, López-Valero I, McKee CS, García-López R, Serrano A, Abad JL, Hanada K, Goñi FM, Guzmán M, Lovat P, Jäättelä M, Alonso A, and *Velasco G (2016) Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization, Autophagy, in press.

Shirasago Y, Shimizu Y, Tanida I, Suzuki T, Suzuki R, Sugiyama K, Wakita T, Hanada K, Yagi K, Kondoh M, and *Fukasawa M (2016) Occludin-knockout human hepatic Huh7.5.1-8-derived cells are completely resistant to hepatitis C virus infection, Biol Pharm Bull, 39, 839–848. doi: 10.1248/bpb.b15-01023

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Copyright 1998 National Institute of Infectious Diseases, Japan