細胞化学部　第1室

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英文原著、総説（2006年以降）

2019年

• Okemoto-Nakamura Y, Tanida I, Yamaji T, Hanada K, Hagiwara K. A PRNP-disrupted human neuroblastoma cell line and its stable transformants expressing prion protein variants. BPB Reports, 2 (5): 73-79 (2019).   FREE Access
  
  
• Hagiwara K, Sato Y, Yamakawa Y, Hara H, Tobiume M, Okemoto-Nakamura Y, Sata T, Horiuchi M, Shibata H, and Ono F. Tracking and clarifying differential traits of classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys. PLoS One, 14(5): e0216807 (2019).   FREE Access
  

2017年

• Hagiwara K, Iwamaru Y, Tabeta N, Yokoyama T, Tobiume M. Evaluation of rapid post-mortem test kits for bovine spongiform encephalopathy (BSE) screening in Japan: Their analytical sensitivity to atypical BSE prions. Prion, 11: 113-127 (2017).   FREE Access
  

2013年

2012年

2011年

• Ono F, Tase N, Kurosawa A, Hiyaoka A, Ohyama A, Tezuka Y, Wada N, Sato Y, Tobiume M, Hagiwara K, Yamakawa Y, Terao K, Sata T.  Atypical L-type bovine spongiform encephalopathy (L-BSE) transmission to cynomolgus macaques, a non-human primate. Jpn J Infect Dis, 64: 81-84 (2011).   FREE Access
  

• Ono F, Terao K, Tase N, Hiyaoka A, Ohyama A, Tezuka Y, Wada N, Kurosawa A, Sato Y, Tobiume M, Hagiwara K, Yamakawa Y, Sata T.  Experimental transmission of bovine spongiform encephalopathy (BSE) to cynomolgus macaques, a non-human primate. Jpn J Infect Dis, 64: 50-54 (2011).   FREE Access
  

2010年

• Shinkai-Ouchi F, Yamakawa Y, Hara H, Tobiume M, Nishijima M, Hanada K, Hagiwara K.  Identification and structural analysis of C-terminally truncated collapsin response mediator protein-2 in a murine model of prion diseases. Proteome Sci . 8: 53 (2010).   FREE Access
  

• Tanaka M, Hara H, Nishina H, Hanada K, Hagiwara K, Maehama T.  An improved method for cell-to-cell transmission of infectious prion.  Biochem Biophys Res Commun, 397: 505-508 (2010).

• Iwamaru Y, Imamura M, Matsuura Y, Masujin K, Shimizu Y, Shu Y, Kurachi M, Kasai K, Murayama Y, Fukuda S, Onoe S, Hagiwara K, Yamakawa Y, Sata T, Mohri S, Okada H, Yokoyama T.  Accumulation of L-type bovine prions in peripheral nerve tissues.  Emerg Infect Dis, 16: 1151-1154 (2010).  FREE Access
  

• Sato Y, Shimonohara,N, Hanaki K, Goto M, Yamakawa Y, Horiuchi M, Takahashi H, Sata T, Nakajima N.  ImmunoAT method: An initial assessment for the detection of abnormal isoforms of prion protein in formalin-fixed and paraffin-embedded tissues.  J Virol Methods, 165: 261-267 (2010).

2009年

• Fukuda S, Iwamaru Y, Imamura M, Masujin K, Shimizu Y, Matsuura Y, Shu Y, Kurachi M, Kasai K, Murayama Y, Onoe S, Hagiwara K, Sata T, Mohri S, Yokoyama T, Okada H.  Intraspecies transmission of L-type-like bovine spongiform encephalopathy detected in Japan.  Microbiol Immunol, 53: 704-707 (2009).

• Sato H, Kusumoto-Matsuo R, Ishii Y, Mori S, Nakahara T, Shinkai-Ouchi F, Kawana K, Fujii T, Taketani Y, Kanda T, Kukimoto I.  Identification of nucleolin as a protein that binds to human papillomavirus type 16 DNA.  Biochem Biophys Res Commun, 387: 525-530 (2009).

• Ogawa M, Shinkai-Ouchi F, Matsutani M, Uchiyama T, Hagiwara K, Hanada K, Kurane I, Kishimoto T.  Shotgun proteomics of Orientia tsutsugamushi.  Clin Microbiol Infect, 15: 239-240 (2009).

• Hara H, Aizaki H, Matsuda M, Shinkai-Ouchi F, Inoue Y, Murakami K, Shoji I, Kawakami H, Matsuura Y, Lai M M, Miyamura T, Wakita T, Suzuki T.  Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein.  J Virol, 83: 5137-5147 (2009).

2008年

• Okemoto-Nakamura Y, Yamakawa Y, Hanada K, Tanaka K, Miura M, Tanida I, Nishijima M, Hagiwara K.  A synthetic fibril peptide promotes clearance of scrapie prion protein by lysosomal degradation.  Microbiol Immunol, 52: 357-365 (2008).

• Masujin K, Shu Y, Yamakawa Y, Hagiwara K, Sata T, Matsuura Y, Iwamaru Y, Imamura M, Okada H, Mohri S, Yokoyama T.  Biological and biochemical characterization of L-type-like bovine spongiform encephalopathy (BSE) detected in Japanese black beef cattle.  Prion, 2: 123-128 (2008).

• Yamamoto T, Ushiki Y, Hara S, Hall W W, Tsukagoshi-Nagai H, Yokoyama T, Tagawa Y, Sata T, Yamakawa Y, Kinoshita N, Tamura F, Hattori S, Irie S.  An advantageous method utilizing new homogenizing device BioMasher and a senstitive ELISA to detect bovine spongiform encephalopathy accurately in brain tissue.  J Virol Methods, 149: 316-325 (2008).

• Katadae M, Hagiwara K, Wada A, Ito M, Umeda M, Casey P J, Fukada Y.  Interacting targets of the farnesyl of transducin γ-subunit.  Biochemistry, 47: 8424-8433 (2008).

2007年

• Hagiwara K, Yamakawa Y, Sato Y, Nakamura Y, Tobiume M, Shinagawa M, Sata T. Accumulation of mono–glycosylated form–rich, plaque–forming PrP^Sc in the second atypical bovine encephalopathy case in Japan.  Jpn J Infect Dis, 60: 305–308 (2007).   FREE Access
  

• Hagiwara K, Nakamura Y, Nishijima M, Yamakawa Y.  Prevention of prion propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice.  Biol Pharm Bull, 30: 835-838 (2007).   FREE Access
  

• Ishii Y, Kondo K, Matsumoto T, Tanaka K, Shinkai-Ouchi F, Hagiwara K, Kanda T.  Thiol-reactive reagents inhibits intracellular trafficking of human papillomavirus type 16 pseudovirions by binding to cysteine residues of major capsid protein L1.  Virol J, 4: 110 (2007).   FREE Access
  

• Yokoyama T, Masujin K, Yamakawa Y, Sata T, Murayama Y, Shu Y, Okada H, Mohri S, Shinagawa M.  Experimental transmission of two young and one suspended bovine spongiform encephalopathy (BSE) cases to bovinized transgenic mice.  Jpn J Infect Dis, 60: 317-320 (2007).   FREE Access
  

• Furuoka H, Yabuzoe A, Horiuchi M, Tagawa Y, Yokoyama T, Yamakawa Y, Shinagawa M, Sata T.  Species-specificity of a panel of prion protein antibodies for the immunohistochemical study of animal and human prion diseases.  J Comp Path, 136: 9-17 (2007).

2006年

• Iwata N, Sato Y, Higuchi Y, Nohtomi K, Nagata N, Hasegawa H, Tobiume M, Nakamura Y, Hagiwara K, Furuoka H, Horiuchi M, Yamakawa Y, Sata T.  Distribution of PrPSc in the cattle with bovine spongiform encephalopathy slaughtered at abattoirs in Japan.  Jpn J Infect Dis, 59: 100-107 (2006).  FREE Access
  

• Furuya K, Kawahara N, Yamakawa Y, Kishida H, Hachiya N S, Nishijima M, Kirino T, Kaneko K.  Intracerebroventricular delivery of dominant negative prion protein in a mouse model of iatrogenic Creutzfeldt-Jakob disease after dura graft transplantation.  Neurosci Lett, 402: 222–226 (2006).

• Yanagisawa Y, Sato Y, Asahi-Ozaki Y, Ito E, Honma R, Imai J, Kanno T, Kano M, Akiyama H, Sata T, Shinkai-Ouchi F, Yamakawa Y, Watanabe S, Katano H.  Effusion and solid lymphomas have distinctive gene and protein expression profiles in an animal model of primary effusion lymphoma.  J Pathol, 209: 464-73 (2006).

• Sato S, Fukasawa M, Yamakawa Y, Natsume T, Suzuki T, Shoji I, Aizaki H, Miyamura T, Nishijima M.  Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein.  J Biochem, 139: 921–930 (2006).

和文総説、解説など

•  中村優子:　ウシ海綿状脳症（BSE）問題とその後.　日本医師会雑誌、147 (6) 1220 (2018).
  
  
• 中村優子、萩原健一:　BSE問題におけるリスク管理とその変遷.　ファルマシア、49: 48-51 (2013).  FREE Access

• 萩原健一、山河芳夫、花田賢太郎:　ヒト・プリオン病­−感染症としての変遷と新たな課題.　ウイルス、59: 155-166 (2009).   FREE Access

• 萩原健一、山河芳夫:　異常型プリオン蛋白質(PrP^Sc)と感染性.　医学のあゆみ、215 (11): 877-890 (2005).

• 萩原健一、山河芳夫:　非定型BSEプリオン.　感染 炎症 免疫、34: 44-46 (2004).