---

| PKR Home | Search | Alignments | Classification | Diseases | 3D Structure | Lab Notebook | Meetings | Researchers | Comments | Contributions |

---

The following classification has been condensed from material provided by Steve Hanks. It represents an attempt to organize the known members of the eukaryotic protein kinase superfamily into distinct families that share basic structural and functional properties. The primary criterion used in the development of this classification scheme is similarity in catalytic domain amino acid sequence. This property, considered alone, has proven to be a good indicator of other features held in common by the different members of a family. Thus kinases having closely-related catalytic domains tend also to: 1) be similar in overall structural topology, 2) have similar modes of regulation, and 3) have similar substrate specificities.

1. AGC Group
   1. AGC Group I
      Cyclic nucleotide regulated protein kinase (PKA & PKG) family
   2. AGC Group II
      Diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family
   3. AGC Group III
      Related to PKA and PKC (RAC/Akt) protein kinase family
      
   4. AGC Group IV
      Kinases that phoshorylate G protein-coupled receptors family
   5. AGC Group V
      Budding yeast AGC-related protein kinase family
   6. AGC group VI
      Kinases that phosphorylate ribosomal protein S6 family
   7. AGC Group VII
      Budding yeast DBF2/20 family
   8. AGC Group VIII
      Flowering plant PVPK1 protein kinase homolog family
   9. AGC Group Other
      Other AGC related kinase families

2. CaMK Group
   1. CaMK Group I
      Kinases regulated by Ca²⁺/CaM and close relatives family
   2. CaMK Group II
      KIN1/SNF1/Nim1 family
   3. CaMK Other
      Other CaMK related kinase families

3. CMGC Group
   1. CMGC Group I
      Cyclin-dependent kinases (CDKs) and close relatives family
   2. CMGC Group II
      ERK (MAP) kinase family
   3. CMGC Group III
      Glycogen synthase kinase 3 (GSK3) family
   4. CMGC Group IV
      Casein kinase II family
   5. CMGC Group V
      Clk family
   6. CMGC Group Other

4. PTK Group - `Conventional' protein-tyrosine kinases

Group I-IX Non-membrane spanning protein-tyrosine kinases
Group IX-XXI membrane spanning protein-tyrosine kinases
1. PTK group I
   Src family
   
2. PTK Group II
   Tec/Atk family
3. PTK Group III
   Csk family
4. PTK Group IV
   Fes (Fps) family
5. PTK Group V
   Abl family
6. PTK Group VI
   Syk/ZAP70 family
7. PTK Group VII
   Tyk2/Jak1 family
8. PTK Group VIII
   Ack family
9. PTK Group IX
   Focal adhesion kinase (Fak) family
10. PTK Group X
    Epidermal growth factor receptor family
11. PTK Group XI
    Eph/Elk/Eck receptor family
12. PTK Group XII
    Axl family
13. PTK Group XIII
    Tie/Tek family
14. PTK Group XIV
    Platelet-derived growth factor receptor family
15. PTK Group XV
    Fibroblast growth factor receptor family
16. PTK Group XVI
    Insulin receptor family
17. PTK Group XVII
    LTK/ALK family
18. PTK Group XVIII
    Ros/Sevenless family
19. PTK Group XIX
    Trk/Ror family
20. PTK Group XX
    DDR/TKT family
21. PTK Group XXI
    Hepatocyte growth factor receptor family
22. PTK Group XXII
    Nematode Kin15/16 family
23. PTK Other membrane spanning kinases
    Other PTK kinase families
5. OPK Group - Other protein kinases (not falling in major groups)
   1. OPK Group I
      Polo family
   2. OPK Group II
      MEK/STE7 family
   3. OPK Group III
      PAK/STE20 family
   4. OPK Group IV
      MEKK/STE11 family
   5. OPK Group V
      NimA family
   6. OPK Group VI
      wee1/mik1 family
   7. OPK Group VII
      Kinases involved in transcriptional control family
   8. OPK Group VIII
      Raf family
   9. OPK Group IX
      Activin/TGFb receptor family
   10. OPK Group X
       Flowering plant putative receptor kinases and close relatives family
   11. OPK Group XI
       PSK/PTK "mixed lineage" leucine zipper domain family
   12. OPK Group XII
       Casein kinase I family
   13. OPK Group XIII
       PKN prokaryotic protein kinase family
   14. OPK Other
       Other protein kinase families (each with no close relatives)

Return to the TOP of this PAGE

Return to the Protein Kinase Resource Home Page

Last modified Wednesday, 31 December 2069 by Anonymous