Click on the picture for a stereo one.
SH3 domain is a small conserved sequence of about 60 amino
acid residues that interacts with proline-rich peptides to
form protein aggregates.
Structurally, the SH3 domain folds as a compact beta-barrel of five
anti-parallel beta-strands which bring the amino and
the carboxyl termini of the domain close to each other. The ligands of the SH3 domains are ten amino acid residue peptides that form a left-
handed polyproline (PPII) helix.
Functionally, the SH3 domain is involved in cell-cell communication and
signal transduction from the cell surface to
the nucleus. It acts as part of an adapter molecule and recruits
downstream proteins in a signalling pathway.
If interested, you can read more information about the different
parts of the domain by clicking on those parts on the
SH3 Walk-Through.
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| SH3 Multiple Alignment
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| Proteins that have SH3 Domain
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By Fariba Fana
September 8, 1997
